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FIGURE 2 Patch-clamp studies testing the effects of bath-applied GLP-1 demonstrated that activating the receptor in hippocampal neurons evoked acute membrane potential changes, proving that GLP-1 receptors exist in the hippocampus and can induce acute neuronal changes ( 140 reduced the frequency of miniature inhibitory and excitatory postsynaptic currents (mEPSCs) (mIPSCs) in rat CA1 pyramidal neurons

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However, their protective efficacy against acetaminophen-induced acute liver failure in humans remains unsubstantiated, and such agents cannot be deemed equivalent to complete protection