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Individuals with MEN 2 carry mutations in the RET proto-oncogene that predispose C-cells to malignant transformation

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Early use of combination therapy may be considered, as the Vildagliptin Efficacy in combination with metfoRmIn for earlY treatment of type 2 diabetes (VERIFY) trial findings suggest that this approach provides superior and more durable effects on blood glucose levels than metformin monotherapy in people with both early-onset (age 150 min/week of moderate- to vigorous-intensity aerobic activity) and be encouraged to reduce sedentary time and break up sitting time with frequent activity breaks

10.2337/dc12-1157 [EL 2

However, they should be taken under the guidance of a healthcare professional to avoid any possible drug interactions