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It affects mainly middle-aged women due to compression of the median nerve in the carpal tunnel The risk of CTS is high in occupations involving exposure to high pressure, high force, repetitive work, and vibrating tools The acute form is relatively uncommon and is due to a rapid and sustained rise of pressure in the carpal tunnel

206 In one small human clinical trial, intravenous infusion of L-tryptophan caused dramatic increases in plasma melatonin levels and had a sleep-inducing effect, regardless of whether it was administered in the daytime or nighttime

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