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Antibodies to the S proteins of SARS-CoV and SARS-CoV-2and, to a much lesser extent, MERS-CoVcan cross-react, and both high-potency neutralizing antibodies that also mediate antibody-dependent cytotoxicity and antibody-dependent cellular phagocytosis 69 , as well as non-neutralizing antibodies, can be elicited against conserved S epitopes 70,71

Within the tumor microenvironment, the IL-6/STAT3 pathway enhances tumor cell survival, proliferation, and invasiveness while simultaneously dampening antitumor immune responses

These additional benefits may make it a particularly attractive option for patients with type 2 diabetes and other metabolic conditions

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