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With the pathways of CBD and autophagy in mind for neurodegeneration and metabolic disease, one is inspired to consider how these compare to the cellular pathways of recently improved FDA treatments for the treatment of glucose homeostasis and obesity in DM that can advocate future clinical utility for CBD

The mechanism is thought to involve binding of the peptide C terminus to the receptor extracellular domain, followed by insertion of the peptide N terminus into the pocket formed by the transmembrane helices and extracellular loops, instigating receptor activation and signalling 19

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