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& Lewis, P
The potential importance of assessing peptides from the intestinal tract, in particular, is illustrated by the fact that surgical procedures that bypass, damage or prevent nutrient contact with the duodenal mucosa are all known to improve blood glucose and body weight control in type 2 diabetes [37]
Instead, collectively, our analyses suggest that in non-interventional settings where most individuals consume meat daily (75233 g/day for European adults 37 ), clearance by the kidney and not dietary intake of TMAO precursors is the major determinant of fasting circulating TMAO levels and therefore of the excess cardiovascular risk associated with elevated TMAO (vegetarians and strict vegans aside, who are infrequent in the MetaCardis cohort with only 65/1741 participants reporting no red meat consumption)
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