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doi: 10.2337/db07-1403

Because of significant adverse effects associated with its use, isotretinoin capsules should be reserved for patients with severe nodular acne who are unresponsive to conventional therapy, including systemic antibiotics

10.1080/2162402x.2018.1503913 Oncoimmunology 134 WangS.-J.LiD.OuY.JiangL.ChenY.ZhaoY.et al (2016)

They then close the container with the lid and give the sample to the test administrator