by Melanie Kuznetsov Introduction: Youve probably seen it: ads, infomercials, or wellness clinic flyers promising a quick fix for B-12 shots: burn fat, rev up energy, shrink waistlines
For example: Fatigue, unexplained weight loss, or abdominal pain may indicate liver disease or cancer Easy bruising, night sweats, or feeling full quickly (early satiety) may suggest a myeloproliferative disorder Swelling in the legs, reduced urine output, or persistent nausea may point to kidney disease In cases of very high B12 from injections (not oral supplements), some people have reported headache, nausea, diarrhea, facial flushing, or skin rash
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Treatment of such an overdose would be mainly supportive, since there is no specific antagonist for B vitamin excess
Despite this relatively short half-life in circulation, the downstream metabolic effects persist for significantly longer due to the sustained activation of lipolytic enzymes and metabolic pathways initiated by the peptide