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For background on the copper tripeptide itself, Wikipedias GHK-Cu overview provides foundational context

After a dose of antibiotics, dealing with chronic GI conditions, or GI surgery, the good bacteria in your gut can be diminished or even relocated

Finally, poor oral bioavailability, incomplete toxicology, uncertain long-term effects, and the absence of controlled human trials remain major limitations

Safety-wise, no serious adverse events have been reported in short-term use, but long-term data is lacking 4

PMC - Therapeutic Peptides and Proteins: Stability Challenges: Discusses regulatory guidelines for peptide stability