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This situation has become more common as regulatory oversight tightens around compounded weight loss medications

Even after gallbladder removal, this risk remains relevant as stones can still form in the bile ducts (choledocholithiasis)

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The weight loss itself accounts for some of this effect, but GLP-1 receptor activation also appears to have direct anti-inflammatory and anti-fibrotic effects in liver tissue

For evidence-based obesity and pharmacotherapy context, the Endocrine Society obesity pharmacotherapy guideline provides clinical background on medication use within broader care