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An elevated methylmalonic acid (MMA) level has been thought to be the most direct, metabolic indicator of B12 deficiency because B12 is the only cofactor required by the enzyme that degrades MMA
Ben Lavine (world leading cardiovascular exercise physiologist at UT Southwest Dallas) for shaping that mindset She works out about 5 to 6 hours a week total broken down like this: Two sessions a week that are CrossFit style, one hour each, first 30 minutes is heavy strength training, last 30 minutes is HIIT (rowing machine, assault bike, lighter cleans with more reps) Two more sessions a week with her girlfriends, about an hour and 20 each, same style but more social and more recovery time between sets Running about 4 to 6 miles a week total, sometimes with her husband, which she genuinely enjoys Weekend hikes with the family, sometimes with a sprint up a hill, but mostly just moving in nature Rest between strength sets is about 2 minutes
Activation of NOX enzymes in Kupffer and hepatic stellate cells induces ROS generation, thereby promoting liver fibrosis and hepatocarcinogenesis 93,94,95,96
