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It is involved in many cellular functions, including antioxidant defense via direct interaction with reactive oxygen/nitrogen species (ROS/RNS) or via activities of detoxication enzymes like GSH peroxidases and GSH- S -transferases [1]

Once the free radicals cross the barrier, they target the brain cells

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, Increased consumption of NADPH may also impair glutathione reductase activity

If concomitant use is warranted, evaluate patients for signs and symptoms of urinary retention or reduced gastric motility when hydrocodone bitartrate and acetaminophen tablets are used concomitantly with anticholinergic drugs