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The Danish drugmaker released the highly anticipated results of its Phase 3 trial of the GLP-1 medication on Friday

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Additionally, in high-fat-diet-induced obese mice, miR-194 overexpression through transcription factor 7-like 2(Tcf7l2) and forkhead box a1(Foxa1) inhibits proglucagon ( Gcg) and Pcsk1 gene transcription, ultimately suppressing GLP-1 synthesis in L-cells [33]

When insurance covers these drugs, out-of-pocket costs can drop to as little as $25 to $50 a month, but that's a big "when." Restrictions on insurance coverage for GLP-1s have been tightening, and doctors say they're spending an increasing amount of time navigating that landscape with patients