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Consistently, the present study revealed that TGF-1 + IL-1 significantly activated NLRP3 inflammasome and induced fibroblast activation, but did not affect the protein level of GSDMD-NT

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Since TNF-alpha is a major cytokine produced by tissue-resident macrophages and circulating TNF-alpha is associated with obesity in T2DM [204], blocking TNF-alpha seems a plausible therapeutic strategy