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Role of glutathione cycle and the pentose phosphate pathway in the detoxification of hydrogen peroxide and biogenic amines in rat brain (Baquer et al., 2009)

doi: 10.1038/s41586-022-05542-y 37 ZuoWHeDLiangCDuSHuaZNieQet al

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Treatment with FOXO4-DRI at 25 M in serum-limited senescent fibroblast and keloid organ culture models promoted apoptosis, decreased G0/G1 phase cells, and induced p53-pS15 nuclear exclusion confirmed by Annexin V-FITC/PI apoptosis assays and TUNEL staining of keloid organ cultures at days 3, 7, and 10