Current clinical practice considerations emphasize the importance of ophthalmologic screening before initiating GLP-1 therapy in patients with longstanding diabetes and implementing more gradual titration schedules in those with known retinal disease to minimize the risk of early worsening
Tirzepatide vs semaglutide mechanism of action Both semaglutide and tirzepatide are GLP-1 receptor agonists, but tirzepatide is also a GIP receptor agonist
Small cuts or scrapes may bleed slightly longer during Mounjaro treatment
Key protocol components, including eligibility criteria, treatment strategies, assignment procedures, follow-up, outcome definitions, causal contrast, identifying assumptions and the data analysis plan, were translated into operational definitions using validated claims-based algorithms and observational analogs of key study design choices
Both treatments are self-administered once per week, on the same day each week