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Hypertension (High Blood Pressure) Extra body weight can cause higher blood pressure, putting additional strain on arteries and the heart, which can lead to various cardiovascular complications over time

When NNMT is overactive (common in obesity), cells struggle with energy production and metabolic efficiency

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However, patients with heart failure should be monitored for volume status and symptoms, particularly if taking diuretics, as gastrointestinal side effects could lead to dehydration

These gastrointestinal issues, including vomiting and abdominal distention, were among the most frequently reported in Phase I trials