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It detoxifies by facilitating transport of toxins out of the body

In the brain, in order to induce tau phosphorylation, oxidative stress can directly interact with protein kinases, particularly glycogen synthase kinase-3 (GSK 3), increasing GSK-3 activity, which subsequently further disrupts its ability to bind to microtubules, accelerating their depolymerisation and interrupting neural signalling (48)

383 However, the development of CETP inhibitors has faced numerous setbacks, 448,449 with several high-profile drug candidates, such as torcetrapib, dalcetrapib, and evacetrapib, failing in phase III clinical trials owing to either a lack of efficacy or off-target adverse effects

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