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The understanding that obesity is a polygenic disease is well-established, with leptin (LEP), leptin receptor (LEPR), melanocortin 4 receptor (MC4R), and proopiomelanocortin (POMC) being prominent contributors

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Clinical Trial Results: Who Responded and Who Did Not In a 2023 Phase 2 trial, the highest dose produced a mean body weight reduction of approximately 24%, but some participants lost less than 5% of body weight, confirming that response is not universal