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Notably, they exhibited lesser interstitial edema (only mild), markedly less damaged neurons than corresponding controls and had no inflammatory reaction ( Table 8 )

65 This protection is achieved through a variety of biological processes, including interactions with transition metals, neutralization of free radicals, modification of the activity of different enzymes, and impacts on intracellular signaling pathways and gene expression

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Furthermore, both IGF-I and the IGF-IR are expressed in the developing glomerulus and patterns of expression are disrupted in animal models and in human examples of renal disease[140]

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