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Based on these findings, we ultimately culminate a rational design of a liposomal apparatus integrating oridonin, maleimide, and TLR2 targeting peptide for GSH depletion and specific cancer cells delivery

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The STEP 1 trial (2021) demonstrated that patients on semaglutide 2.4 mg weekly lost an average of 14.9% of body weight over 68 weeks, compared to 2.6% for placebo

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We generated 100 structural models of the FOXO4 FH bound to the p53 TAD2 , starting with the 3D structure of FOXO4 FH (PDB: 1E17 55 ) and the p53 TAD2 domain as an elongated chain