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While the kinetic rate constants could not be accurately determined for GLP-1 QMP, GLP-1 QMP/LX (0.2 nM) showed an almost 600-fold higher binding affinity compared to GLP-1 WT (Fig

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This variant leads to an amino acid substitution that may impair enzyme activity and alter local T3 availability, particularly in the brain and pituitary

Furthermore, it has been shown that physiological high estradiol levels correlate with increased leptin sensitivity and that reduced leptin sensitivity after oophorectomy can be restored with estrogen treatment (154)