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Because it is a peptide, it is highly susceptible to denaturation. Denaturation is a process where the protein structure of the medication breaks down or unfolds

doi: 10.1016/j.jalz.2019.07.002 126 LiH.WangP.HuangL.LiP.ZhangD

But the anatomy makes sense

Important safety note : If folate deficiency is detected alongside B12 deficiency, B12 replacement must be started before folate to avoid worsening neurological symptoms