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The main risk is intensified gastrointestinal side effects (nausea, vomiting, diarrhea)

Avoid placing medication in direct sunlight

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28,29 While not associated with clinical benefit in HFrEF, recently, these drugs have been studied in patients with HFpEF demonstrating improvements in clinical outcomes such as health-related quality of life (STEP-HFpEF) as well as reductions in cardiovascular death and HF events (SUMMIT)

The determination of when to apply the brace and the frequency and duration of use should be strictly at the discretion of the treating physician