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J Basic Clin Physiol Pharm 2014

10.1016/j.jmb.2007.09.041 21 CsiszarJ.HorvathE.VaryZ.GalleA.BelaK.BrunnerS.et al

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In the context of mucosal inflammation, the activation of NADPH oxidase (NOX) and inducible nitric oxide synthase (iNOS) by inflammatory cytokines leads to the production of superoxide and nitric oxide by intestinal epithelial cells (IECs), neutrophils, and macrophages ( Both ROS and RNS have been implicated in IBD pathogenesis, with a particular role in CD initiation and progression ( These ROS promote cell damage and harm tissue integrity by preventing the accumulation of antioxidant defenses in host cells

Paglia, P.E