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Mitochondrial function measurement Mitochondrial function was assessed using established assays as described previously [20]

Tracking cognitive effects Subjective assessment provides useful but limited information

Interestingly, despite the presence of superoxide dismutase (SOD) ( k = 2.4 10 9 M 1 s 1 ) 36 , the resulting concentration of H 2 O 2 is significantly smaller than the concentration of superoxide, indicating that the model is able to respond well to a transient increase in ROS, maintaining low H 2 O 2 concentrations

Partial protection likely reflects differences in tissue types, or the assay protocols used in the other studies, but our results confirm that all the drugs tested exhibit radioprotection at some concentration, in one or both assays (Supplementary Table 4)

Melegh B, Kerner J, Sandor A, et al