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Regulatory approvals have focused on weight loss efficacy as the primary endpoint with cardiovascular benefits considered secondary outcomes

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GLP-1s change how your body communicates with food GLP-1 medications influence multiple systems: Hunger and fullness hormones Brain reward and impulse signals Blood sugar regulation Digestion and stomach emptying But these systems dont update instantly

The presence of water allows for various degradation mechanisms including hydrolysis, oxidation, and microbial contamination that are not concerns with freeze-dried material