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In summary, the understanding of CGRPs dual role in vascular and non-vascular processes provides important knowledge of migraine pathophysiology and may shape the direction of upcoming therapeutic approaches

System One Reward Chemistry Hijacked is about how ultra-processed food substances flood the dopamine system, causing receptors to downregulate

Interestingly, this effect seems to be mediated through hepatic glucagon signalling, as infusion into the portal vein induced a satiating response whereas infusion into the inferior vena cava did not (64)

it's a direct result of how the medication changes your digestive process

This can sometimes lead to functional hypothalamic amenorrhoea a temporary absence of periods while your body adjusts to the new normal