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No single receptor accounts for its activity

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After completion of the single-dose cohorts, an expansion panel randomized postmenopausal females at a ratio of 1:1:1:1 to receive IV doses of anti-ActA 10 mg/kg alone, anti-GDF8 6 mg/kg alone, co-administration of anti-GDF8 6 mg/kg + anti-ActA 10 mg/kg, or placebo

Ive reviewed discontinuation data from every major GLP-1 and GIP agonist trial published in the last five years

This review seeks to consolidate ferroptosis studies in OA, providing insights into the targeting of its critical elements for innovative OA therapies