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[115], in a meta-analysis with network pharmacologya discipline which attempts to understand drug actions and interactions with multiple targetsincluding ten studies (both RCTs and non-RCTs) involving 576 patients with MASLD, highlighted an association between metformin and reduced triglyceride (TG) levels (mean decrease (MD) = 0.17, 95% CI = 0.26 to 0.08), total cholesterol (MD = 0.29, 95% CI = 0.47 to 0.10), and insulin resistance (MD = 0.42, 95% CI = 0.82 to 0.02)

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doi: 10.1182/bloodadvances.2024015703