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Mounjaro and Zepbound contain tirzepatide, a dual GLP-1/GIP agonist

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People with severe kidney disease face increased risks because both dehydration-related complications from tirzepatide and bupropion metabolite accumulation from impaired renal clearance create a compounded problem

4.2 Spexin and galanin receptor signaling Spexin is a highly conserved 14-amino-acid peptide identified through bioinformatic analysis of the human genome