GLP-1 stands for glucagon-like-peptide 1 agonists, which regulate appetite by increasing naturally occurring hormones called incretins, making people feel full longer
The STEP-HFpEF trial with GLP-1 RAs semaglutide on HFpEF and obese patients demonstrated enhanced exercise capacity (7.9-point increase in KCCQ-CSS compared to placebo over 52 weeks) but lacked sufficient evidence on cardiovascular endpoints [9,11,12]
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doi:10.1002/oby.24067 Old VJ, Davies MJ, Papamargaritis D, Choudhary P, Watson EL