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cuproptosis potentially immunosuppressive) complicate combination therapy design and necessitate sophisticated, context-dependent therapeutic sequencing

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Dysfunction of the CFTR (cystic fibrosis transmembrane conductance regulator) protein is associated with an increased risk of GI tumors, both in patients with cystic fibrosis and in sporadic GI cancers (353)

As there are transient conditions that can cause albuminuria that are benign and not related to CKD (Table 7), at least 2 of 3 abnormal ACRs over at least 3 months are required before diabetic nephropathy is diagnosed (Figure 1)