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Your TCF7L2 gene variants and other genetic factors dictate how youll respond to each of these supplements

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These benefits were highlighted in 2019 when the Lancet published a meta-analysis of seven clinical trials showing that these treatments reduced hospital admission by 9%, all-cause mortality by 12% and deaths associated with kidney disease by 17% ( While these data are astoundingwith yearly progress in efficacy, we should consider that around 9% of patients receiving these game-changer treatments (Table 1)

However, there is no official FDA guidance mandating lifelong use, and treatment duration remains an individualized clinical decision

Full scans of blots presented in cropped form in the manuscript are shown in Supplementary Fig