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Reviewers, including the Indian Journal of Dermatology, Venereology and Leprology paper on this exact topic, note that how long brightening lasts after stopping hasn't been properly studied yet treat it as maintenance, not a one-time fix

The major enzymatic antioxidants of the lungs are SODs, catalase, and glutathione peroxidases as well as heme oxygenase-1, thioredoxins, peroxiredoxins, and glutaredoxins [41]

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This suggests the dual mechanism might provide additional appetite control beyond GLP-1 alone