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The benefits in each component mutually reinforce one another through positive feedback along the microbiota-barrier-immune axis, ultimately driving systemic remodeling of the intestinal microenvironment in UC

Furthermore, these results were verified in three RCTs (ALVEOLI, FACTT, and SAILS trials), 122,123,124 with a significant interaction between the three subphenotypes and treatment strategies in the ALVEOLI and FACTT trials

Exercise resulted in a dramatic decrease in GSH plasma levels (Fig