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Disclosure of interest: PRESTIGE-AF is funded by a grant of the EU Research and Innovation programme Horizon 2020 (Grant Agreement number: 754517)

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Tirzepatide represents a significant advancement in the treatment of type 2 diabetes and obesity

It belongs to a novel class of agents known as triple receptor agonists, meaning it simultaneously activates three distinct hormone receptors: the glucagon-like peptide-1 (GLP-1) receptor, the glucose-dependent insulinotropic polypeptide (GIP) receptor, and the glucagon receptor