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However, the isoform A (exon 11-splice variant) of IR (IR-A), normally expressed in fetal tissues, promotes cell growth in response to IGF-2 stimulation and has been reported to be abundantly expressed in some IGF-1R deficient leiomyosarcomas (Sciacca et al, 2002)

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To further substantiate this relationship, we evaluated whether data fitted a model where eGFR causally mediates the increase of TMAO concentration with age