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These processes may help prevent or delay early neurodegeneration but may not reverse or halt disease once protein aggregation and synaptic loss are well underway. Even though the trials enrolled people with early Alzheimers, Edison noted that the disease likely had been developing silently for decades

Using the same spot over and over can lead to the buildup of scar tissue (lipohypertrophy), which can impair absorption and make injections more difficult and painful

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Haem and iron acquisition systems have also demonstrated a role in sensing host environmental cues to mediate interactions with host epithelial cells