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Similar weight and hemoglobin A1c improvements : Both groups improved in blood sugar and body mass index (BMI), though the non-GLP-1 group had slightly better numbers overall

Pair fats with fiber-rich foods to slow gastric emptying and enhance GLP-1 responses

Target-driven exit rules: transition the clinical mindset from treating for a trial period to exiting upon target achievement. For instance, a 36 months metabolic optimization window should be pre-set to achieve a clinically meaningful weight-loss threshold and improve IR markers

Here are some of the most studied pathways: Fiber : Viscous soluble fibers (like those in oats, beans, or chia seeds) slow digestion and stimulate specialized L-cells in the gut that release GLP-1