Contact your GP or prescribing clinician if you experience: Heartburn that persists despite lifestyle modifications and over-the-counter treatments Difficulty swallowing (dysphagia) Pain when swallowing (odynophagia) Unintentional weight loss beyond expected therapeutic effect Persistent vomiting, particularly if containing blood or resembling coffee grounds Black, tarry stools (melaena) suggesting gastrointestinal bleeding Severe, persistent abdominal pain Symptoms of anaemia (fatigue, pallor, breathlessness) Seek immediate medical attention (call 999 or attend A&E) if you develop: Severe chest pain, particularly if radiating to the arm, neck, or jaw (to exclude cardiac causes) Vomiting large amounts of blood Sudden, severe abdominal pain Signs of dehydration from persistent vomiting According to NICE guidance on gastro-oesophageal reflux disease (CG184), patients with persistent reflux symptoms lasting more than 48 weeks despite optimal treatment should be considered for further investigation
There are four main types of melanoma, and they can all look different
Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI
The term is not limited to physiological conditions, and includes psychogenic conditions or perceived impairment without a formal diagnosis of pathology or disorder
Regular follow-ups allow the healthcare provider to watch for any signs of new autoimmune problems or flares of existing ones
