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134 , 3213S3214S (2004)
Excessive MDA in liver tissue will consume a large amount of antioxidative factors, such as SOD and GSH, which can protect liver from the attacks of free radicals, but once the balance is broken, SOD and GSH will be unable to protect liver against the excessively increased MDA (22,23)
This activation triggers a cascade of downstream signaling events leading to the activation of the PI3K-AKT/PKB and Ras-MAPK pathways
Treatment with retinoid X receptor agonist IRX4204 ameliorates experimental autoimmune encephalomyelitis
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