A 2003 study by Staresinic, Sebecic, Patrlj, and colleagues in Journal of Orthopaedic Research used a rat Achilles tendon transection model with BPC-157 administered intraperitoneally once daily at 10 g/kg, 10 ng/kg, or 10 pg/kg and reported improved load-to-failure, Young's modulus of elasticity, and Achilles functional index scores, reduced tendon defect size by day 14, and increased tendocyte outgrowth in vitro with specific numerical effect sizes and p-values not reported in the abstract
Another approach is to mitigate oxidative stress by administration of antioxidants such as ascorbate and Nacetyl cysteine
For a few years, a loophole in compounding rules had allowed specialty pharmacies to make and market these peptides
117 Only three of the studies included in this review were on NAC, but data were not divided into the separate compounds and there is no public access to the original studies that were published in 1972 and 1989, making it difficult to assess the use of NAC in this context
This allows assessment of tolerance before increasing to standard therapeutic doses of 1-2mg daily