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A small proportion of people with obesity are not suitable for anti-obesity medicines

The medication is administered as a once-weekly subcutaneous injection , with doses typically starting at 0.25 mg (an initiation dose for tolerability, not therapeutic effect) and gradually increasing according to the licensed titration schedule

The TRIUMPH program spans four core trials covering general obesity, obesity plus knee osteoarthritis, obesity with cardiovascular disease, and obesity with type 2 diabetes, with nested protocols studying sleep apnea (OSA) within those same participant groups

Thermal injury of the rectum can be prevented by controlling the temperature of the coffee enema, and the risks of electrolyte imbalance or septicemia due to frequent enema are not relevant for patients undergoing a one-time procedure for small bowel preparation