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Equal amounts of protein (20 g per lane) were loaded onto 10% SDS-PAGE gels, transferred to PVDF membranes (Bio-Rad), and blocked with 5% non-fat milk in TBS-T buffer

MNs/GLP-1RAs@NPs-WYRGRL suppressed the progression of RA through promoting the polarization of synovial macrophages to the M2 type To clarify whether MNs/GLP-1RAs@NPs-WYRGRL could alleviate the inflammatory response of RA by regulating the polarization state of synovial macrophages, this study detected the types of synovial macrophages and the cytokines they secrete in each group

Tirzepatide Dosing and Administration Guidelines Tirzepatide is administered as a once-weekly injection, making it a convenient option for many patients