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Triple Hormone Receptor Agonist Retatrutide for Metabolic Dysfunction-Associated Steatotic Liver Disease Nature Medicine Phase 2a trial demonstrated retatrutide 12 mg achieved 82.4% mean reduction in liver fat at 24 weeks, with 86% of participants normalizing liver fat levels below 5%

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the National Science & Technology Major Project of China Key New Drug Creation and Manufacturing Program (2018ZX09735001 (M.W.W.), 2018ZX09711002002005 (D.Y.) and 2018ZX09711002002002 (Y.J.))

The body weight and food intake of the mice were measured biweekly

(D) MCF7 cells were exposed to 10nM -estradiol (-E2) 40nM sodium selenite (Se)