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Castillo-Castaeda PC, Garca-Gonzlez A, Bencomo-Alvarez AE, Barros-Nuez P, Gaxiola-Robles R, Mndez-Rodrguez LC, et al

Dark circles develop because of various factors, including heredity, age, and natural skin color, along with late-night device usage and persistent stress

However, their clinical translation is often impeded by inherent challenges such as poor bioavailability, limited aqueous solubility, and rapid systemic clearance, which collectively hinder their effective delivery to targeted ocular tissues [347]

Smeitink, J

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