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Influence of GLP1 receptor agonists on dopamine regulation Dopamine plays a prominent role in the immediate reinforcing/rewarding effects of drugs, and dysregulation of the dopamine system is thought to contribute (as a predisposing factor and/or a consequence of chronic substance use) to the addicted state (Volkow, Michaelides, et al., 2019)

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This single-pathway approach has been extensively studied, with clinical trials showing average weight losses of 1015% of body weight over 68 weeks in adults with obesity

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