In patients with acromegaly (enhanced growth hormone levels) IGF-1 levels are also increased and these levels correlate with the severity of the disease
In clinical trials, participants who took the highest dose of the once-daily pill achieved an average weight loss of 12.4 percent, or 27.3 pounds, after 72 weeks, compared with 2.2 pounds with the placebo
Castellano-Escuder P, Gonzlez-Domnguez R, Wishart DS, Andrs-Lacueva C, Snchez-Pla A
Those with plasma B12 levels above 813 pg/mL (600 pmol/L) had a 1.74 to 4.72 times higher risk of being diagnosed with cancer within one year compared to those with levels in the normal range
According to the Lingvay et al study, 51% of those who used semaglutide and 62% of those who used tirzepatide lost weight