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Although AREDS2 revealed that no significant decrease was observed in the risk of advanced AMD for lutein/zeaxanthin, subgroup analyses showed that for participants in the lowest quintile of dietary intake (mean = 696 g/day), lutein/zeaxanthin exhibited protective effects against AMD progression possibly because the lutein/zeaxanthin consumption of the individuals was similar to that of other well-nourished groups [103]

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13 Contraindications A panel review of 49 case reports concluded that individuals with certain genetic polymorphisms might have an increased risk of developing insulin autoimmune syndrome with the consumption of ALA supplements